CBD for AnxietyMar 03, 2022
Aimee Prasek, PhD
Most research on cannabidiol (CBD) has looked at its possible benefits for anxiety disorders, perceived stress, performance anxiety, and more general feelings of anxiousness. And though the research is still in its infancy and needs improvement, current evidence indicates it has substantial potential for anxiety-related concerns [1, 5, 6, 7, 8, 13, 16, 20]. Considering that CBD is considered well-tolerated for many, its application may be particularly helpful for mild or moderate concerns where prescriptions might not be necessary.
CBD Dosage and Use
It's important to not there is no established dosage for CBD and individuals may respond quite differently to different dosages. However, a common dose range for CBD in adults is 15-30 mg daily. With some conditions, such as those involving pain or inflammation, the recommended dose is often higher, but it seems to be best-tolerated and most effective for anxiety, sleep, and mood in this moderate range.
After discussing with a doctor, look for a high quality, broad-spectrum, all natural, non-GMO hemp product that is THC-free (i.e. measures less than 0.3% THC). Avoiding THC is particularly important for some individuals looking to support anxiousness as THC may increase anxiety for some individuals. CBD is commonly take in doses of 10-15 mg twice times daily, with or without meals, or in a single dose of 20-30 mg daily.
CBD Side Effects
As noted, CBD is generally considered well-tolerated. However, CBD can cause side effects. These side effects can be more confusing given the unreliability of the purity and dosage of CBD in products (which is why purchasing a high-quality product is essential).
Side effects of CBD may inlude:
- Dizziness and lightheadedness
- Dry Mouth
- Increased Appetite
- Lowered blood pressure
The most common side effect reported is very mild sedation, though that is usually not a problem for those with high anxiety, and may be a welcome effect for those with sleep troubles. Like most things that are calming, adding CBD to other sedating medications, or combining CBD with alcohol, may cause excess sedation.
There is too little information about the safety of CBD during pregnancy or while breastfeeding, so it is not recommended.
Research suggests many side effects that occur with CBD use are likely the result of drug-to-drug interactions between CBD and other medications an individual may be taking. That's why it's so important to speak with your doctor before starting any supplement, and this is particularly true with CBD.
Here's how these interactions occur: CBD is broken down by the body via the same pathway as many prescription drugs. If multiple compounds are competing in this pathway (e.g., CBD and a prescription drug), then something called "altered concentration" can occur. This means that too little or too much of the drug is left in the body. When too little remains, a drug may no longer work as intended. When too much remains, side effects may increase. Penn State College of Medicine has a really handy list of medications that may be impacted by altered concentration due to a combination with cannabinoids. Unfortunately, this list does not make any distinctions between CBD or THC, but it provides some guidance. Bring this list to your doctor before starting any CBD product.
Penn State also found potentially serious interactions between prescription CBD and THC products and the following products:
- Warfarin and other blood thinners
- Amiodarone (heart medication)
- Levothyroxine (thyroid medication)
- Seizure medications (clobazam, lamotrigine, valproate)
CBD Supplements at Natural Mental Health
- Sleep CBD is a blend of broad-spectrum CBD (30 mg per serving) combined with 5 mg of CBN (cannabinol) and 3 mg of melatonin. CBN is a form of phytocannabinoid shown to be more specifically helpful for sleep, and melatonin is nature’s internal timekeeper, helping set a more consistent bedtime. CBD Sleep may improve a variety of challenging sleep issues, and is especially helpful for those who have trouble falling asleep.
- Calm CBD combines 30 mg of broad-spectrum CBD with 200 mg of l-theanine, an amino acid that can also help reduce anxiety and stabilize mood. Together, they may improve stress resilience and calm anxiety without sedation. Taken at bedtime, CBD Calm may also be helpful for those who tend to wake in the middle of the night.
- Restore CBD gummies are infused with the highest quality, all-natural, US-grown hemp. Each gummy offers a precise dose of broad-spectrum CBD to support your endocannabinoid system with naturally occurring, plant-based ingredients. This synergy of multiple cannabinoids work together for the greatest impact to restore your natural resilience.
*Note: Some of the supplements discussed in this article can cause side effects, but many people tolerate them much better than prescription medications. They are generally considered safe, however, they should not be started without your doctor’s knowledge and supervision. If you are taking medication already, be sure to talk with your doctor before adding any of these items. If you are considering going off medication, remember never to stop your medication suddenly—always consult with your doctor about how to safely taper off any psychiatric medication. See terms.
**These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
- Abrams, D. (2018). The therapeutic effects of Cannabis and cannabinoids: An update from the National Academies of Sciences, Engineering and Medicine report. European journal of internal medicine, 49, 7-11.
- Atakan, Z. (2012). Cannabis, a complex plant: different compounds and different effects on individuals. Therapeutic advances in psychopharmacology, 2(6), 241-54. doi:10.1177/2045125312457586
- Atalay, S., Jarocka-Karpowicz, I., & Skrzydlewska, E. (2019). Antioxidative and Anti-Inflammatory Properties of Cannabidiol. Antioxidants, 9(1), 21. https://doi.org/10.3390/antiox9010021
- Babson, K. A., Sottile, J., & Morabito, D. (2017) Cannabis, cannabinoids, and sleep: A review of the literature. Current Psychiatry Reports, 19(23). doi: 10.1007/s11920-017-0775-9. [full-text here]
- Ballard, C. R., & Junior, M. R. M. (2019). Health benefits of flavonoids. In Bioactive compounds (pp. 185-201). Woodhead Publishing.
- Blessing, E. M., Steenkamp, M. M., Manzanares, J., & Marmar, C. R. (2015). Cannabidiol as a potential treatment for anxiety disorders. Neurotherapeutics, 12(4), 825-836. doi: 10.1007/s13311-015-0387-1
- Bridgeman, M. B., & Daniel T. A. (2017). Medicinal cannabis: History, pharmacology, And implications for the acute care setting. P&T: A peer-reviewed journal for formulary management, 42(3), 180-188.
- Cox-Georgian, D., Ramadoss, N., Dona, C., & Basu, C. (2019). Therapeutic and medicinal uses of terpenes. In Medicinal Plants (pp. 333-359). Springer, Cham.
- García-Gutiérrez, M.S., Navarrete, F., Gasparyan, A., Austrich-Olivares, A., Sala, F., & Manzanares, J. (2020). Cannabidiol: A Potential New Alternative for the Treatment of Anxiety, Depression, and Psychotic Disorders. Biomolecules, 10(11). https://doi.org/10.3390/biom10111575
- Kocis, P, T., & Vrana, K, E. (2020). Delta-9-Tetrahydrocannabinol and Cannabidiol Drug-Drug Interactions. Med Cannabis Cannabinoids, 3:61-73. doi: 10.1159/000507998
- Kuhathasan, N., Dufort, A., MacKillop, J., Gottschalk, R., Minuzzi, L., & Frey, B. N. (2019). The use of cannabinoids for sleep: A critical review on clinical trials. Experimental and Clinical Psychopharmacology, 27(4), 383–401. https://doi.org/10.1037/pha0000285
- Lee, C. H., & Giuliani, F. (2019). The Role of Inflammation in Depression and Fatigue. Frontiers in immunology, 10, 1696. https://doi.org/10.3389/fimmu.2019.01696
- Leonard, B. E. (2014). Impact of inflammation on neurotransmitter changes in major depression: An insight into the action of antidepressants, Progress in Neuro-Psychopharmacology and Biological Psychiatry, 48. 261-267. https://doi.org/10.1016/j.pnpbp.2013.10.018.
- Morales, P. et al. (2017). Molecular targets of the phytocannabinoids: A complex picture. Progress in the chemistry of organic natural products, 103, 103-131. doi:10.1007/978-3-319-45541-9_4
- Murillo-Rodríguez, E., Millán-Aldaco, D., Palomero-Rivero, M., Mechoulam, R., & Drucker-Colín, R. (2006). Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats. FEBS Letters, 580(18), 4337-4345. https://doi.org/10.1016/j.febslet.2006.04.102.
- Noreen N., Muhammad, F., Akhtar, B., Azam, F., & Anwar, M. I. (2018). Is cannabidiol a promising substance for new drug development? A review of its potential therapeutic applications. Crit Rev Eukaryot Gene Expr, 28(1), 73-86. doi: 10.1615/CritRevEukaryotGeneExpr.2018021528.
- Sales, A. J., Crestani, C. C., Guimarães, F. S., Joca, S. (2018). Antidepressant-like effect induced by Cannabidiol is dependent on brain serotonin levels. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 86. 255-261. https://doi.org/10.1016/j.pnpbp.2018.06.002.
- Sales, A. J., Fogaça, M. V., Sartim, A. G., et al. (2019). Cannabidiol induces rapid and sustained antidepressant-like effects through increased BDNH signaling and synaptogenesis in the prefrontal cortex. Mol Neurobiol, 56, 1070–1081. doi:10.1007/s12035-018-1143-4.
- Sarris, J. et al. (2020). Medicinal cannabis for psychiatric disorders: A clinically-focused systematic review. BMC Psychiatry, 20(1). doi:10.1186/s12888-019-2409-8
- Shannon, S., Lewis, N., Lee, H., & Hughes, S. (2019). Cannabidiol in Anxiety and Sleep: A Large Case Series. The Permanente journal, 23, 18–041. https://doi.org/10.7812/TPP/18-041
- Wong, S. S., & Wilens, T. E. (2017). Medical cannabinoids in children and adolescents: a systematic review. Pediatrics, 140(5).