Shop
CBD Effects and Side Effects | Natural Mental Health

CBD Effects and Side Effects

Feb 18, 2022

Timothy Culbert, MD, IFMCP

CBD effects and possible uses

CBD is a non-intoxicating cannabinoid that has effects on the body and brain but does not cause the sensory and psychological effects that THC does. Scientific research to evaluate the therapeutic applications for CBD is just in its infancy. The marketing hype is definitely overselling at this point, but the science will catch up and CBD (and THC) will likely have some clear and more general applications for use with public health issues like anxiety, sleep, and pain. 

Current promising applications being investigated include (see sources near bottom of page):

  • Anti-seizure
  • Anxiety (with growing support for social anxiety applications)
  • Chronic pain
  • Sleep (with more research to support sleep issues related to anxiousness and stress)
  • Inflammatory bowel diseases
  • Migraines

CBD side effects

CBD is well tolerated, even in large doses. HoweverCBD can cause side effects. These include: dry mouth, diarrhea, reduced appetite, drowsiness, dizziness, and fatigue. Another cause for concern is the unreliability of the purity and dosage of CBD in products. That concern highlights the importance of choosing a high quality product that undergoes rigorous third-party testing. 

CBD contraindications

Research also suggests many side effects that occur with CBD use are likely the result of drug-to-drug interactions between CBD and other medications an individual may be taking (e.g., blood thinners). How does this work? Some medications are changed and broken down by the liver. Cannabidiol might decrease how quickly the liver breaks down some medications. In effect, using cannabidiol along with some medications that are broken down by the liver might increase the effects and/or side effects of some medications.  

This is a key reason to check with your primary doctor before starting CBD, particularly if you're on any medication or adding to another supplement or over-the-counter product that causes sleepiness. Other examples of this type of interaction can include (but are not limited to):

  • Antipsychotics
  • Benzodiazepines
  • Opioids
  • Antihistamines
  • Herbal products to support sleep
  • Alchohol

Additionally, there are other medication interactions with CBD that can be serious. Penn State College of Medicine has a really handy list of medications that may be impacted by altered concentration due to a combination with cannabinoids. Unfortunately, this list does not make any distinctions between CBD or THC, but it provides some guidance. Bring this list to your doctor before starting any CBD product.  

Penn State also found potentially serious interactions between prescription CBD and THC products and the following products:

  • Warfarin and other blood thinners
  • Amiodarone (heart medication)
  • Levothyroxine (thyroid medication)
  • Seizure medications (clobazam, lamotrigine, valproate)

CBD Supplements at Natural Mental Health

  • Sleep CBD is a blend of broad-spectrum CBD (30 mg per serving) combined with 5 mg of CBN (cannabinol) and 3 mg of melatonin. CBN is a form of phytocannabinoid shown to be more specifically helpful for sleep, and melatonin is nature’s internal timekeeper, helping set a more consistent bedtime. CBD Sleep may improve a variety of challenging sleep issues, and is especially helpful for those who have trouble falling asleep. 

  • Calm CBD combines 30 mg of broad-spectrum CBD with 200 mg of l-theanine, an amino acid that can also help reduce anxiety and stabilize mood. Together, they may improve stress resilience and calm anxiety without sedation. Taken at bedtime, CBD Calm may also be helpful for those who tend to wake in the middle of the night.

 

  • Restore CBD gummies are infused with the highest quality, all-natural, US-grown hemp. Each gummy offers a precise dose of broad-spectrum CBD to support your endocannabinoid system with naturally occurring, plant-based ingredients. This synergy of multiple cannabinoids work together for the greatest impact to restore your natural resilience. 

 


SOURCES
  1. Abrams, D. (2018). The therapeutic effects of Cannabis and cannabinoids: An update from the National Academies of Sciences, Engineering and Medicine report. European journal of internal medicine49, 7-11.
  2. Atakan, Z. (2012). Cannabis, a complex plant: different compounds and different effects on individuals. Therapeutic advances in psychopharmacology, 2(6), 241-54. doi:10.1177/2045125312457586
  3. Atalay, S., Jarocka-Karpowicz, I., & Skrzydlewska, E. (2019). Antioxidative and Anti-Inflammatory Properties of Cannabidiol. Antioxidants, 9(1), 21. https://doi.org/10.3390/antiox9010021
  4. Ballard, C. R., & Junior, M. R. M. (2019). Health benefits of flavonoids. In Bioactive compounds (pp. 185-201). Woodhead Publishing.
  5. Bridgeman, M. B., & Daniel T. A. (2017). Medicinal cannabis: History, pharmacology, And implications for the acute care setting. P&T: A peer-reviewed journal for formulary management, 42(3), 180-188.
  6. Cox-Georgian, D., Ramadoss, N., Dona, C., & Basu, C. (2019). Therapeutic and medicinal uses of terpenes. In Medicinal Plants (pp. 333-359). Springer, Cham.
  7. García-Gutiérrez, M.S., Navarrete, F., Gasparyan, A., Austrich-Olivares, A., Sala, F., & Manzanares, J. (2020). Cannabidiol: A Potential New Alternative for the Treatment of Anxiety, Depression, and Psychotic Disorders. Biomolecules, 10(11). https://doi.org/10.3390/biom10111575  
  8. Kocis, P, T., & Vrana, K, E. (2020). Delta-9-Tetrahydrocannabinol and Cannabidiol Drug-Drug Interactions. Med Cannabis Cannabinoids, 3:61-73. doi:10.1159/000507998
  9. Lee, C. H., & Giuliani, F. (2019). The Role of Inflammation in Depression and Fatigue. Frontiers in immunology10, 1696. https://doi.org/10.3389/fimmu.2019.01696
  10. Leonard, B. E. (2014). Impact of inflammation on neurotransmitter changes in major depression: An insight into the action of antidepressants, Progress in Neuro-Psychopharmacology and Biological Psychiatry, 48. 261-267. https://doi.org/10.1016/j.pnpbp.2013.10.018.
  11. Morales, P. et al. (2017). Molecular targets of the phytocannabinoids: A complex picture. Progress in the chemistry of organic natural products, 103, 103-131. doi:10.1007/978-3-319-45541-9_4
  12. Noreen N., Muhammad, F., Akhtar, B., Azam, F., & Anwar, M. I. (2018). Is cannabidiol a promising substance for new drug development? A review of its potential therapeutic applications. Crit Rev Eukaryot Gene Expr, 28(1), 73-86. doi: 10.1615/CritRevEukaryotGeneExpr.2018021528. 
  13. Sales, A. J., Crestani, C. C., Guimarães, F. S., Joca, S. (2018). Antidepressant-like effect induced by Cannabidiol is dependent on brain serotonin levels. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 86. 255-261. https://doi.org/10.1016/j.pnpbp.2018.06.002.
  14. Sales, A. J., Fogaça, M. V., Sartim, A. G., et al. (2019)Cannabidiol induces rapid and sustained antidepressant-like effects through increased BDNH signaling and synaptogenesis in the prefrontal cortex. Mol Neurobiol, 56, 1070–1081. doi:10.1007/s12035-018-1143-4. 
  15. Sarris, J. et al. (2020). Medicinal cannabis for psychiatric disorders: A clinically-focused systematic review. BMC Psychiatry, 20(1). doi:10.1186/s12888-019-2409-8
  16. Wong, S. S., & Wilens, T. E. (2017). Medical cannabinoids in children and adolescents: a systematic review. Pediatrics140(5).
  17.  

 


 

 


 

RESILIENCE IS YOUR NATURAL STATE

Discover your Resilience Type with the Resilience Quiz

After completing the quiz, you can get your free tailored mini-course, full of integrative practices and supplement ideas to help you reclaim your most resilient self.

Learn more
Resilience Type Quiz: A person wearing a white t-shirt and green pants is shown holding up falling beams.

Why Nutrition is Important: Understanding Food as Information

Nov 17, 2022

Practice Self-Compassion By Easing Up On Yourself

Oct 13, 2022

Helpful support delivered right to your inbox.

From the tangible ways you can reclaim your joy, calm, and focus—to new workshops and special offers, we’ll make your journey to wellness easier.

MEDICAL DISCLAIMER

This content is for informational and educational purposes only. It is not intended to provide medical advice and is not a replacement for advice and treatment from a medical professional. Consult your doctor or other qualified health professional regarding specific health questions. Individuals providing content to this website take no responsibility for possible health consequences of any person or persons reading or following the information in this educational content. It is also essential to consult your physician or other qualified health professional before beginning any diet change, supplement, or lifestyle program.