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CBD and Antidepressants

CBD and Antidepressants

Feb 24, 2022

 

Henry Emmons, MD

  

Research suggests many of the side effects that occur with CBD are likely the result of drug-to-drug interactions between CBD and other medications an individual may be taking. That's why it's so important to speak with your doctor before starting any supplement, and this is particularly true with CBD.

Here's how these interactions occur: CBD is broken down by the body via the same pathway as many prescription drugs. If multiple compounds are competing in this pathway (e.g., CBD and a prescription drug), then something called "altered concentration" can occur. This means that too little or too much of the drug is left in the body. When too little remains, a drug may no longer work as intended. When too much remains, side effects may increase.

This altered concentration should be considered when taking CBD with antidepressants and any other prescription, supplement, or over-the-counter product that causes sleepiness. Other examples of this type of interaction can include (but are not limited to):

  • Antipsychotics
  • Benzodiazepines
  • Opioids
  • Antihistamines
  • Herbal products to support sleep
  • Alchohol

Additionally, there are other medication interactions with CBD that can be serious. Penn State College of Medicine has a really handy list of medications that may be impacted by altered concentration due to a combination with cannabinoids. Unfortunately, this list does not make any distinctions between CBD or THC, but it provides some guidance. Bring this list to your doctor before starting any CBD product.  

Penn State also found potentially serious interactions between prescription CBD and THC products and the following products:

  • Warfarin and other blood thinners
  • Amiodarone (heart medication)
  • Levothyroxine (thyroid medication)
  • Seizure medications (clobazam, lamotrigine, valproate)

 

CBD Supplements at Natural Mental Health

  • Sleep CBD is a blend of broad-spectrum CBD (30 mg per serving) combined with 5 mg of CBN (cannabinol) and 3 mg of melatonin. CBN is a form of phytocannabinoid shown to be more specifically helpful for sleep, and melatonin is nature’s internal timekeeper, helping set a more consistent bedtime. CBD Sleep may improve a variety of challenging sleep issues, and is especially helpful for those who have trouble falling asleep. 

  • Calm CBD combines 30 mg of broad-spectrum CBD with 200 mg of l-theanine, an amino acid that can also help reduce anxiety and stabilize mood. Together, they may improve stress resilience and calm anxiety without sedation. Taken at bedtime, CBD Calm may also be helpful for those who tend to wake in the middle of the night.

 

  • Restore CBD gummies are infused with the highest quality, all-natural, US-grown hemp. Each gummy offers a precise dose of broad-spectrum CBD to support your endocannabinoid system with naturally occurring, plant-based ingredients. This synergy of multiple cannabinoids work together for the greatest impact to restore your natural resilience. 

 

 

 

*Note: Some of the supplements discussed in this article can cause side effects, but many people tolerate them much better than prescription medications. They are generally considered safe, however, they should not be started without your doctor’s knowledge and supervision. If you are taking medication already, be sure to talk with your doctor before adding any of these items. If you are considering going off medication, remember never to stop your medication suddenly—always consult with your doctor about how to safely taper off any psychiatric medication. See terms.

**These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

 


SOURCES
  1. Abrams, D. (2018). The therapeutic effects of Cannabis and cannabinoids: An update from the National Academies of Sciences, Engineering and Medicine report. European journal of internal medicine49, 7-11.
  2. Atakan, Z. (2012). Cannabis, a complex plant: different compounds and different effects on individuals. Therapeutic advances in psychopharmacology, 2(6), 241-54. doi:10.1177/2045125312457586
  3. Atalay, S., Jarocka-Karpowicz, I., & Skrzydlewska, E. (2019). Antioxidative and Anti-Inflammatory Properties of Cannabidiol. Antioxidants, 9(1), 21. https://doi.org/10.3390/antiox9010021
  4. Ballard, C. R., & Junior, M. R. M. (2019). Health benefits of flavonoids. In Bioactive compounds (pp. 185-201). Woodhead Publishing.
  5. Bridgeman, M. B., & Daniel T. A. (2017). Medicinal cannabis: History, pharmacology, And implications for the acute care setting. P&T: A peer-reviewed journal for formulary management, 42(3), 180-188.
  6. Cox-Georgian, D., Ramadoss, N., Dona, C., & Basu, C. (2019). Therapeutic and medicinal uses of terpenes. In Medicinal Plants (pp. 333-359). Springer, Cham.
  7. García-Gutiérrez, M.S., Navarrete, F., Gasparyan, A., Austrich-Olivares, A., Sala, F., & Manzanares, J. (2020). Cannabidiol: A Potential New Alternative for the Treatment of Anxiety, Depression, and Psychotic Disorders. Biomolecules, 10(11). https://doi.org/10.3390/biom10111575  
  8. Kocis, P, T., & Vrana, K, E. (2020). Delta-9-Tetrahydrocannabinol and Cannabidiol Drug-Drug Interactions. Med Cannabis Cannabinoids, 3:61-73. doi: 10.1159/000507998
  9. Lee, C. H., & Giuliani, F. (2019). The Role of Inflammation in Depression and Fatigue. Frontiers in immunology10, 1696. https://doi.org/10.3389/fimmu.2019.01696
  10. Leonard, B. E. (2014). Impact of inflammation on neurotransmitter changes in major depression: An insight into the action of antidepressants, Progress in Neuro-Psychopharmacology and Biological Psychiatry, 48. 261-267. https://doi.org/10.1016/j.pnpbp.2013.10.018.
  11. Morales, P. et al. (2017). Molecular targets of the phytocannabinoids: A complex picture. Progress in the chemistry of organic natural products, 103, 103-131. doi:10.1007/978-3-319-45541-9_4
  12. Noreen N., Muhammad, F., Akhtar, B., Azam, F., & Anwar, M. I. (2018). Is cannabidiol a promising substance for new drug development? A review of its potential therapeutic applications. Crit Rev Eukaryot Gene Expr, 28(1), 73-86. doi: 10.1615/CritRevEukaryotGeneExpr.2018021528. 
  13. Sales, A. J., Crestani, C. C., Guimarães, F. S., Joca, S. (2018). Antidepressant-like effect induced by Cannabidiol is dependent on brain serotonin levels. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 86. 255-261. https://doi.org/10.1016/j.pnpbp.2018.06.002.
  14. Sales, A. J., Fogaça, M. V., Sartim, A. G., et al. (2019)Cannabidiol induces rapid and sustained antidepressant-like effects through increased BDNH signaling and synaptogenesis in the prefrontal cortex. Mol Neurobiol, 56, 1070–1081. doi:10.1007/s12035-018-1143-4. 
  15. Sarris, J. et al. (2020). Medicinal cannabis for psychiatric disorders: A clinically-focused systematic review. BMC Psychiatry, 20(1). doi:10.1186/s12888-019-2409-8
  16. Wong, S. S., & Wilens, T. E. (2017). Medical cannabinoids in children and adolescents: a systematic review. Pediatrics140(5).

 

 

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This content is for informational and educational purposes only. It is not intended to provide medical advice and is not a replacement for advice and treatment from a medical professional. Consult your doctor or other qualified health professional regarding specific health questions. Individuals providing content to this website take no responsibility for possible health consequences of any person or persons reading or following the information in this educational content. It is also essential to consult your physician or other qualified health professional before beginning any diet change, supplement, or lifestyle program.