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NAC Supplements for Anxiousness

Aug 18, 2020

by Henry Emmons, MD

[adapted from The Chemistry of Calm]

p.s., You've read Part 1 of this series and the introductory article about balancing GABA and glutamate, right? If not, head to those articles first.

NAC Benefits | NAC and Anxiety

NAC is short for n-acetylcysteine. You may have never heard of it before, but it has been used for years in emergency rooms for patients who are at risk for liver damage from something they have ingested (e.g., too much acetominophen). It protects the liver for the same reason it protects the brain: it works as a powerful antioxidant, boosting levels of the body’s own primary antioxidant—glutathione.

As researchers have realized the connection between glutamate/GABA balance and anxiety conditions, they have begun experimenting with NAC. Recently it has been used with one of the most complex anxiety illnesses—the spectrum of compulsive disorders (including OCD). Remarkably, researchers found that this simple and inexpensive nutritional supplement works for such hard-to-treat problems as pathological gambling13 and compulsive hair-pulling (trichotillomania).14  

NAC Dosage & Use*

NAC typically comes in a dose of 600 mg, and may be taken once or twice daily. 

NAC Side Effects*

Some of my patients have had mild headaches or stomach upset, but it is generally well tolerated, especially when taken with food.

NAC Supplements**

  • NAC from Xymogen contains 600 mg per capsule. Note that this is a professional formula, so you'll need to use the code "nmhclub" to purchase the product. 

 

*Note: Some of the supplements discussed in this series can cause side effects, but many people tolerate them much better than prescription medications. They are generally considered safe, however, they should not be started without your doctor’s knowledge and supervision. If you are taking medication already, be sure to talk with your doctor before adding any of these items. If you are considering going off medication, remember never to stop your medication suddenly—always consult with your doctor about how to safely taper off any psychiatric medication.

**These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.  

 

 


READ ARTICLE

Rhodiola for Joy and Calm

Rhodiola is one of a class of herbs known as “adaptogens”. These are tonic herbs that aren’t considered to be medicinal—that is they aren’t used to relieve a specific symptom. Adaptogens can have a broader positive impact on health, supporting one or more of the body’s important systems like the immune system or metabolism. In the case of rhodiola, it is primarily supporting the stress system—i.e., the adrenals and the autonomic nervous system. Read more.

 


SOURCES
  1. Hassel, B., & Dingledine, R. (2006). Glutamate. In Siegel,G. J., Albers, R. W., Brady, S. T., & Price, D. L. (Eds.), Basic neurochemistry: Molecular, cellular, and medical aspects (267-290). San Diego, CA: Academic Press. 
  2. Kim, A. H., et al. (2002). Blocking excitotoxicity. In Marcoux, F. W., & Choi, D. W. (Eds.), Neuroprotection (3-36). New York: Springer.
  3. Krimer, L. S., et al. (1998). Dopaminergic regulation of cerebral cortical microcirculation. Nature Neuroscience, 1, 286-289.
  4. Wichers, M., & Maes, M. (2002). The psychoneuroimmuno-pathophysiology of cytokine induced depression in humans. International Journal of Neuropsychopharmacology, 5, 375-438.
  5. Peled, R., et al. (2008). Breast cancer, psychological distress and life events among young women BMC Cancer, 8.
  6. Alhaj, H. A., et al. (2006). Effects of DHEA administration on episodic memory, cortisol and mood in healthy young men: A double-blind, placebo-controlled study. Psychopharmacology, 188(4), 541-551.
  7. Darbinyan, V., et al. (2007). Clinical trial of Rhodiola Rosea L. extract SHR-5 in the treatment of mild to moderate depression. Nordic Journal of Psychiatry, 61(5), 343-348.
  8. Bystritsky, A., et al. (2008). A pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder (GAD). The Journal of Alternative and Complementary Medicine, 14(2), 175-180.
  9. Khanum, F., et al. (2005). Rhodiola rosea: A versatile adaptogen. Comprehensive Reviews in Food Science and Food Safety, 4, 55-62.
  10. Lombard, J. (2006, September). Neurobiology of mood and cognition: Strategies and protocols of neurotransmitter balance. Presented at Great Lakes Conference.
  11. Kobayashi, K., et al. (1998). Effects of L-theanine on the release of alpha-brain waves in human volunteers. Journal of the Agricultural Chemical Society of Japan, 72(2), 153-157.
  12. Lake, J. (2008). Integrative Management of Anxiety. Psychiatric Times, 25(1), 13-16.
  13. Grant, J., et al. (2007). N-acetyl cysteine, a glutamate-modulating agent, in the treatment of pathological gambling: A pilot study. Biological Psychiatry, 62(6), 652-657.
  14. Grant, J., et al. (2009). N-acetylcysteine, a glutamate modulator, in the treatment of trichotillomania. Archives of General Psychiatry, 66(7), 756-763.
  15. Mori, M., et al., (2002). Beta-alanine and taurine as endogenous agonists at glycine receptors in rat hippocampus in vitro. The Journal of Physiology, 539, 191-200.
  16. Wu, H., et al. (2005). Mode of action of taurine as a neuroprotector. Brain Research, 1038(2), 123-131.
  17. Palatnik, A., et al. (2001). Double-blind, controlled, crossover trial of inositol versus fluvoxamine for the treatment of panic disorder. Journal of Clinical Psychopharmacology, 21(3), 335-339.
  18. Abdou, A., et al. (2006). Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans. BioFactors, 26, 201-208.
  19. Kinrys, G., et al. (2009). Natural remedies for anxiety disorders: Potential use and clinical applications. Depression and Anxiety, 26, 259-265.
  20. Akhondzadeh, S., et al. (2001). Passionflower in the treatment of generalized anxiety disorder: A pilot double-blind randomized controlled trial with oxazepam. Journal of Clinical Pharmacy and Therapeutics, 26, 363-367.
  21. Yuan, C. S., et al. (2004). The gamma-aminobutyric acidergic effects of valerian and valerenic acid on rat brainstem neuronal activity. Anesthesia and Analgesia, 98, 353-358.
  22. Panijel, M. (1985). Therapy of symptoms of anxiety. Therapiewoche, 41, 4659-4668.

 

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MEDICAL DISCLAIMER

This content is for informational and educational purposes only. It is not intended to provide medical advice and is not a replacement for advice and treatment from a medical professional. Consult your doctor or other qualified health professional regarding specific health questions. Individuals providing content to this website take no responsibility for possible health consequences of any person or persons reading or following the information in this educational content. It is also essential to consult your physician or other qualified health professional before beginning any diet change, supplement, or lifestyle program.