Curcumin, the magical little part of turmeric (also deemed its principal curcuminoid), has been the subject of a lot of research in recent years. The dynamic nature of curcumin’s biological effects make it an interesting compound to researchers who study common chronic health concerns, such as those associated with joints, the cardiovascular system, glucose metabolism, brain function, mood, and cell-cycle regulation.*[1-6]

The mechanisms underlying curcumin’s effects are diverse and are still in need of exploration, but it is known that curcumin has powerful antioxidant activity and multiple molecular targets, including transcription factors, cell cycle proteins, cytokines, chemokines, enzymes (e.g., COX-2), receptors, and adhesion molecules.[7] These effects may make curcumin relevant for a lot of health issues.*

Benefits of Turmeric

• Provides antioxidant & cell-protective activity*
• Supports joint health & helps relieve minor pain associated with physical activity*
• Supports the health of organs & systems by modulating the production of cytokines and other signaling molecules*
• Supports the body’s efforts to promote healthy cell growth & inhibit unhealthy cell growth in certain cell lines*
• Supports brain/neuronal health and a healthy mood*
• Supports a healthy microbial environment*

Turmeric Safety and Dosage

Turmeric has been safely consumed for thousands of years, and its medicinal compound curcumin has an outstanding safety profile. Phase I clinical trials using up to 8 g/d for four months did not result in any discernable toxicities.[30] Mild gastrointestinal distress can sometimes accompany curcumin supplementation, but this may be minimized by consuming the supplement with food. Current doses in clinical trials using BCM-95 range from 500 mg/d to 1000 mg/d.*

Turmeric/Curcumin Supplement at Resilient Remedies

Fire Quencher includes a 100% pure turmeric extract standardized to curcumin, demethoxycurcumin, bisdemethoxycurcumin, and essential oils of turmeric rhizome. This natural composition can ease the body and support a healthy mood.*

SOURCES

1. Yang F, Lim GP, Begum AN, et al. Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem. 2005 Feb 18;280(7):5892-901. [PMID: 15590663]
2. Chandran B, Goel A. A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytother Res. 2012 Nov;26(11):1719-25. [PMID: 22407780]
3. Garcea G, Berry DP, Jones DJ, et al. Consumption of the putative chemopreventive agent curcumin by cancer patients: assessment of curcumin levels in the colorectum and their pharmacodynamic consequences. Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):120-25. [PMID: 15668484]
4. Ghosh S, Banerjee S, Sil PC. The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update. Food Chem Toxicol. 2015 Sep;83:111-24. [PMID: 26066364]
5. Sanmukhani J, Satodia V, Trivedi J, et al. Efficacy and safety of curcumin in major depressive disorder: a randomized controlled trial. Phytother Res. 2014 Apr;28(4):579-85. [PMID: 23832433]
6. Baum L, Lam CW, Cheung SK, et al. Six-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer disease. J Clin Psychopharmacol. 2008 Feb;28(1):110-13. [PMID: 18204357]